Analysis of intraperitoneal hyperthermic chemoperfusion combined with interleukin-2 in the treatment of malignant ascites
10.3760/cma.j.issn.0254-9026.2013.04.013
- VernacularTitle:腹腔热灌注化疗联合白介素-2治疗中老年人恶性腹水临床分析
- Author:
Xiang LING
;
Xiaolang WANG
- Publication Type:Journal Article
- Keywords:
Drug therapy,combination;
Diathermy;
Interleukin-2;
Ascites
- From:
Chinese Journal of Geriatrics
2013;(4):397-399
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of intraperitoneal hyperthcrmic chemoperfusion in combination with interleukin 2 in the treatment of malignant ascites.Methods A total of 47 patients aged 47-75 years with malignant ascites were randomly divided into two groups:the experimental group and the control group.All patients received a closed drainage and were treated with paclitaxel liposome,cisplatin (DDP),interleukin-2 and dexamethasone by intraperitonealinfusion.Patients were asked to change the body position.In addition,the patients in experimental group were received the high frequency hyperthermia immediately at a temperature of 42℃ to 43℃ for 90 minutes.Results The remission rate (RR) was higher in the experimental group than in the control group (75.0 ％ vs.43.5％,x2 =4.85,P＜0.05).The median survival time (MST) was longer in the experimental group than in the control group (34 weeks vs.21 weeks,P＜0.05).There were no significant differences in adverse reaction incidences between groups (P ＞ 0.05).Conclusions Compared with intraperitoneal chemoperfusion alone,the intraperitoneal hyperthermic chemoperfusion has a higher RR and longer MST with no increased adverse reaction incidence,which can be in the clinical application.
