Correlation of the single nucleotide polymorphisms of IL-15 with chemotheray response in childhood acute lymphoblastic leukemia

VernacularTitle:IL-15单核苷酸多态性与儿童急性淋巴细胞白血病治疗反应相关性
Author: Yu DING ; Yan MIAO ; Xiang WANG ; Yanjing TANG ; Huiliang XUE ; Jing CHEN ; Lixia DING ; Jingyan TANG ; Benshang LI ; Shuhong SHEN
Publication Type:Journal Article
Keywords: interleukin-15; acute lymphoblastic leukemia; single nucleotide polymorphisms; child
From: Journal of Clinical Pediatrics 2013;(7):632-636
CountryChina
Language:Chinese
Abstract: Objectives To investigate the correlation between single nucleotide polymorphisms (SNP) in interleu-kin-15 (IL-15) and treatment response in childhood acute lymphoblastic leukemia (ALL). Methods Genomic DNA samples extracted from remission bone marrow cells of ALL patients were genotyped by MassArray. Five SNPs (rs10519612, rs10519613, rs17007695, rs17015014 and rs35964658) in IL-15 and their association to minimal residual disease (MRD) status in the end of induction therapy were studied. Results SNP rs17007695 was associated with the early response in children with ALL(P=0.049) and the incidence of positive MRD after induction therapy in CC genotype carriers was 1.8 times more than that in TT genotype carriers. Haplotype analysis of these five SNPs showed that the frequency of haplotype CACGG in MRD positive group was 2.1 times higher than that in MRD negative group (P=0.035). Conclusions IL-15 gene polymorphism was associated with the early treatment response in Han Chinese children with acute lymphoblastic leuke-mia.