Clinical therapy of Candesartan plus CSDP on elderly hypertensive patients with renal dysfunction
10.3760/cma.j.issn.1008-6315.2012.13.005
- VernacularTitle:坎地沙坦联合复方丹参滴丸对老年原发性高血压患者肾功能的影响
- Author:
Jinping CHEN
;
Yujing LIU
;
Hua YU
;
Qing CHEN
;
Xianglan LI
- Publication Type:Journal Article
- Keywords:
Candesartan;
CSDP;
Hypertensive patient;
Renal dysfunction
- From:
Clinical Medicine of China
2012;(z1):11-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapy effect of candesartan plus CSDP on elderly hypertensive patients with renal dysfunction.Methods Eighty elderly patients with essential hypertension and renal dysfunction were selected as our subjects.All subjects were randomly divided into candesartan group and candesartan + CSDP group,every group for 40 subjects.Patients in candesartan group were treated with 4 mg candesartan once per day for 6 months.Patients in candesartan + CSDP group were given CSDP 10 capsules three times / day beside 4 mg candesartan,once per day for 6 months.The levels of Cr,BUN,Ccr changes were measured.Results Two therapy strategies can decrease blood pressure and the decrease rate of blood pressure in candesartan + CSDP group was higher than that of candesartan group.The level of Cr,BUN in patients with candesartan + CSDP group after treatment performing were (104.6 ± 6.5) μmol/L,(6.21 ± 4.80) mmol/L,lower than that in before treatment (196.8 ± 2.6) μ mol/L,(9.84 ± 3.20) mmol/L.And the Ccr increased from (58.1 ± 4.9)ml/min to (117.2 ± 6.4)ml/min.The differences were significant (t =2.213,2.302,2.136,P ＜ 0.05).However the differences between before and after treatment with only candesartan treat weren't significant (P ＜ 0.05).Conclusion Candesartan + CSDP might show a synergistic effect compared with candesartan in term of curing elderly hypertensive patients with renal dysfunction.
