Control analysis between mifepristone and medroxyprogesterone in the treatment of patients with perimenopausal dysfunctional uterine bleeding

VernacularTitle:米非司酮与甲羟孕酮片治疗围绝经期功能失调性子宫出血的对照分析
Author: Haixia YANG
Publication Type:Journal Article
Keywords: Dysfunctional uterine bleeding; Perimenopausal; Mifepristone; Medroxyprogesterone
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(8):1182-1183
CountryChina
Language:Chinese
Abstract: Objective To compare the effect between mifepristone and medroxyprogesterone in the treatment of patients with perimenopausal dysfunctional uterine bleeding.Methods 90 patients with perimenopausal dysfunctional uterine bleeding were randomly divided into two groups after diagnostic curettage surgery,the control group (n =45 cases) and the observation group(n =45 cases).The patients in the control group were treated with medroxyprogesterone,while the patients in the treatment group were treated with mifepristone.The endometrial thickness,anemia and menstrual flow were analyzed after three months.Results The total efficient rates were 71.1％ in the control group and 88.9％ in the observation group.There was a significant difference between two groups (P ＜ 0.01).The endometrial thickness,anemia and menstrual flow were improved after treatment in both groups,which were more significantly improved in the treatment group (P ＜ 0.05).Conclusion The mifepristone is significantly better than medroxyprogesterone acetate tablets in the control perimenopausal dysfunctional uterine bleeding.