Long noncoding RNA in digestive system neoplasms
10.3969/j.issn.1000-8179.2013.15.015
- VernacularTitle:lncRNA在消化系统肿瘤中的研究进展
- Author:
Yongguo SHI
;
Keming WANG
- Publication Type:Journal Article
- Keywords:
lncRNA;
digestive system neoplasms;
tumor markers
- From:
Chinese Journal of Clinical Oncology
2013;(15):938-940
- CountryChina
- Language:Chinese
-
Abstract:
Long noncoding RNA (lncRNA) comprises a group of RNAs that are longer than 200 nucleotides. The lncRNA does not contain functional open reading frames and cannot encode proteins. RNA accounts for a large proportion in the total noncoding RNAs. The number, type, and function of lncRNA are unclear, so they have been called the dark matter of the genome. With the applica-tion of a new generation of gene sequencing technology, lncRNA is found to be involved in the mechanisms mediating the signal trans-duction pathway, regulating the cell cycle, and inducing cell apoptosis. In this article, the authors summarized the up-to-date research progress on lncRNA in digestive system neoplasms in China and overseas to provide new insights into the genetic diagnosis and treat-ment of digestive system neoplasms in clinics.
