Epithelial-mesenchymal transition and stemness of cancer cells
10.3969/j.issn.1000-8179.2013.15.016
- VernacularTitle:上皮间充质转化与肿瘤干细胞的研究进展*
- Author:
Hua GUO
;
Ning ZHANG
- Publication Type:Journal Article
- Keywords:
EMT;
cancer stem cells;
MET;
tumor metastasis
- From:
Chinese Journal of Clinical Oncology
2013;(15):941-945
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition (EMT) is an important biological process in embryonic development and tumori-genesis. In this process, epithelial tumor cells can obtain mesenchymal phenotypes and promote tumor invasion and metastasis. EMT is controlled by multiple transcription factors, signal pathways, and microRNAs. EMT and cancer stem cells are closely related. EMT also promotes the self-renewal ability of tumor cells and the overexpression of EMT-related markers in tumor cells with stemness. Some mi-croRNAs can control EMT process and stemness. In this study, recent developments on EMT and cancer stem cells in tumor metastasis were summarized to provide new insights into target therapy of tumor metastasis and recurrence.
