Adjunctive efficacy of microbial ecological agents for elderly patients with acute pancreatitis
10.3760/cma.j.issn.0254-9026.2013.06.016
- VernacularTitle:微生态制剂辅助治疗老年急性胰腺炎的疗效观察
- Author:
Ming CHEN
;
Zewei CAO
- Publication Type:Journal Article
- Keywords:
Probiotics;
Pancreatitis
- From:
Chinese Journal of Geriatrics
2013;(6):627-629
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the auxiliary efficacy of microbial ecological agents for elderly patients with acute pancreatitis.Methods Totally 144 elderly patients with acute pancreatitis were selected and randomly divided into the observe group and the control group (n=72,each).All patients received the regular treatment and enteral nutrition.Microbial ecological agents were added in enteral nutrition in the observe group.The levels of endotoxin (ET),tumor necrosis factor (TNF-α),interleukin (IL)-6 and C-reactive protein (CRP)in peripheral blood were determined and compared between the two groups.The clinical index and the occurrence of adverse reactions were observed.Results Compared with pretreatment,the levels of ET,TNF-α,IL-6,CRP were significantly reduced in both two groups after treatment.The levels of ET,IL-6,TNF-α,CRP were lower in the observe group than in the control group [(0.14±0.07)EU/ml vs.(0.31±0.12)EU/ml,(44.77±17.82)pg/ml vs.(63.25 ± 14.26)pg/ml,(0.15 ± 0.05)μg/L vs.(0.29 ± 0.14)μg/L,(108.33 ±11.84)mg/Lvs.(135.41±21.45)mg/L,t=14.722,43.824,7.071,5.811,respectively,allP＜0.05].The recovery time of symptoms and signs,the anal exsufflation time and hospitalization time were shorter in the observe group than in the control group [(25.8±4.8)h vs.(36.4±6.2)h,(30.9±6.7)hvs.(44.4±7.3)h,(24.9±3.2)hvs.(37.6±3.4)h,(6.9±0.4)dvs.(13.1±1.2)d,t=4.747,4.401,10.125,33.443,respectively,all P＜0.05].There were no statistically differences in death rate and the occurrence of adverse reactions between the two groups (x2 =0.15,0.64,both P＞0.05).Conclusions Microbial ecological agents are safe and effective as an adjuvant therapy for elderly patients with acute pancreatitis.It is worth promoting in clinical medicine.
