Relationship between Helicobacter pylori infection and gastric carcinogenesis in elderly patients
10.3760/cma.j.issn.0254-9026.2013.06.015
- VernacularTitle:幽门螺杆菌感染与老年患者胃黏膜癌变的相关性研究
- Author:
Wenxin LI
- Publication Type:Journal Article
- Keywords:
Helicobacter infection;
Helicobacter,pylori;
Stomach neoplasms
- From:
Chinese Journal of Geriatrics
2013;(6):624-626
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between Helicobacter pylori (HP) infection and gastric carcinogenesis,and to investigate its mechanism.Methods Totally 333 elderly patients with different degrees of gastric mucosal lesions in our hospital were selected.Patients were divided into 4 groups:chronic superficial gastritis group (n=86),chronic atrophic gastritis group (n=92),gastric ulcer group (n=80) and gastric cancer group (n=75).HP infection in patients were detected by paraffin-embedded tissue sections and ELISA.The gene expressions of c-myc,p16 and p53 were detected by immunohistochemical SP method,and the results were analyzed.Results HP infection positive rate was significantly higher in gastric cancer group than those in the chronic superficial gastritis group and chronic atrophic gastritis group (both P＜ 0.05).There were no significant differences in the expression rates of c-myc,p16 and p53 between HP positive and negative patients in chronic superficial gastritis group (all P＞0.05).There were differences in the expression rates of cmyc and p53 (both P＜0.05),while the expression rate of p16 had no significant difference between HP positive and negative patients in chronic atrophic gastritis group (P ＞ 0.05).There were differences in the expression rates of c-myc,p16 and p53 between HP positive and negative patients in gastric ulcer group and gastric cancer group (all P ＜ 0.05).Conclusions There is a certain correlation between Helicobacter pylori infection and gastric carcinogenesis.It is important to take anti-inflammatory treatment timely and actively to prevent gastric cancer in patients with HP infection in gastric mucosal lesions.
