Association between SLC30A8 gene polymorphisms and diabetes mellitus after renal transplantation
10.3969/j.issn.2095-4344.2013.31.006
- VernacularTitle:SLC30A8基因多态性与肾移植后糖尿病的相关性*☆
- Author:
Airong YU
;
Xing FAN
;
Huiming LIU
;
Huawen XIN
;
Xiaochun WU
- Publication Type:Journal Article
- Keywords:
organ transplantation;
renal transplantation;
posttransplantation diabetes mellitus;
SLC30A8 gene;
rs13266634;
single nucleotide polymorphism;
risk factor;
allele;
diabetes;
provincial grants-supported paper
- From:
Chinese Journal of Tissue Engineering Research
2013;(31):5613-5619
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Previous studies have found that the susceptibility genes of adiponectin gene and calpain 10 gene of type 2 diabetes are closely related with the incidence of diabetes in Chinese renal transplantation patients. So, are other susceptibility genes of type 2 diabetes also associated with posttransplantation diabetes mel itus? OBJECTIVE:To investigate the association between the zinc transporter solute carrier family 30 member 8 (SLC30A8) gene polymorphism and the posttransplantation diabetes mel itus. METHODS:A total of 97 patients with posttransplantation diabetes mel itus and 301 patents without posttransplantation diabetes mel itus (control group) were selected, and then the SLC30A8 gene rs13266634 genotype was detected with real-time PCR method. The association between gene polymorphism and posttransplantation diabetes mel itus was analyzed with Logistic regression test. RESULTS AND CONCLUSION:There were significant differences in al ele frequencies and genotype distributions of rs13266634 between the patients with and without posttransplantation diabetes mel itus (P<0.05). After adjustments of age, sex, body weight and body mass index, the incidence of posttransplantation diabetes mel itus of the CC genotype patients was 2.108 times to that of the TT genotype patients (odds ratio=2.108, 95%confidence interval:1.075-4.131, P=0.044);and the incidence of posttransplantation diabetes mel itus of the CC+CT genotype patients was 1.862 times to that of the TT genotype patients (odds ratio=1.862, 95%confidence interval:1.049-3.306, P=0.034). The results suggest that the C-al ele in rs13266634 of SLC30A8 gene is the independent risk factor of posttransplantation diabetes mel itus.
