The Effect of Preoperative Oral Application of Bovine Colostrum on Endotoxemia and TNF-alpha in Abdominal Surgery.
- Author:
Hyun Il SEO
1
;
Woo Kyu JEON
;
Jin Ho KANG
;
Si Young LIM
;
Seung Sei LEE
;
Byung Ho SOHN
;
Chang Hak RYU
;
Jun Ho SHIN
;
Hung Dai KIM
;
Won Kon HAN
;
Tae Yun OH
;
Hee Yeon WOO
;
Hyo Soon PARK
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. wookyu.jeon@samsung.com
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Bovine colostrums;
Endotoxemia;
TNF-alpha;
Abdominal surgery
- MeSH:
Colostrum*;
Endotoxemia*;
Fever;
Horseshoe Crabs;
Humans;
Incidence;
Leukocytosis;
Plasma;
Prospective Studies;
Tumor Necrosis Factor-alpha*
- From:Journal of the Korean Surgical Society
2006;70(6):462-469
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We conducted this study to assess the effect of oral application of bovine colostrum on the plasma endotoxin and TNF-alpha following the abdominal surgery. METHODS: 46 patients who underwent the abdominal surgery were evenly enrolled in a prospective, randomized, double blind and placebo-controlled study. The patients were preoperatively managed by oral application of 20 g of a bovine colostrums or placebo (nonfat dried milk) per a day for 3 days. In both groups, endotoxin was sequentially determined pre-, intra- and postoperatively by a modified limulus amebocyte lysate test. TNF-alpha and CRP were also measured. The clinical course was followed and compared in both groups. RESULTS: The colostrum group showed significantly lower level of endotoxin and TNF-alpha compared to the placebo group. CRP did not differ in both groups. Clinical event did not occur in both group until the discharge. Colostrum group tends to have a lower incidence of fever and leukocytosis without statistic significance. CONCLUSION: Prophylactic preoperative oral application of bovine colostrum lower the plasma level of perioperative endotoxin and TNF-alpha. Further studies were needed for the relation of clinical effect and preoperative oral application of bovine colostrum.
