Clinical study of Gemcitabine and Cisplatin combination chemotherapy in treatment of 72 cases of patients with urothelial cell carcinoma

VernacularTitle:吉西他滨联合顺铂治疗尿路上皮癌72例的临床研究
Author: Jing XIAO ; Haijun HOU ; Yichen ZHU ; Zhipeng WANG ; Jian ZHANG ; Yuwen GUO ; Ye TIAN
Publication Type:Journal Article
Keywords: Urothelial cell carcinoma; Drug therapy,combination; Gemcitabine; Cisplatin; Therapies,investigational
From: International Journal of Surgery 2013;(3):171-173
CountryChina
Language:Chinese
Abstract: Objective To explore the efficacy and safety of Gemcitabine and Cisplatin combination chemotherapy in treatment of muscle-invasive urothelial cell carcinoma.Methods Analyse of 72 cases of patients with muscle-invasive urothelial cell carcinoma receiving chemotherapy from September 2010 to September 2012,including 47 male and 25 female,the avarage age was 65 (86-33).All patients were received GC chemotherapy (Gemcitabine 800-1 000 mg/m2,ivgtt,dl,d8,d15; Cisplatin 70 mg/m2,ivgtt,d2).Efficacy was reviewed after 1 cycle of chemotherapy.Results Fifty-one cases in all the patients completed two or more chemotherapy cycles and CR 10 cases,PR 27 cases,total effective rate was 51.39％ (37/72).The main toxic reactions included nausea,vomit,myelosuppression,and then damage of liver and renal function.Cconclusion GC regimen is a good choice for urothelial cell carcinoma.Close follow-up and the usage of adjuvant drugs can contribute to reduce the side effect of chemotherapy.