Clinical research of uterine artery chemoembolization combined with radiotherapy for intermediate and advanced cervical cancer
10.3760/cma.j.issn.1673-4904.2013.15.012
- VernacularTitle:子宫动脉化疗栓塞术联合放疗治疗中晚期宫颈癌的临床研究
- Author:
Xiaoyan WANG
;
Jianhua CHEN
;
Yongli LIU
;
Ning LI
;
Huamei ZHANG
;
Jing LI
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Radiotherapy,computer-assisted;
Embolization,therapeutic
- From:
Chinese Journal of Postgraduates of Medicine
2013;(15):34-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of uterine artery chemoembolization combined with radiotherapy in the treatment of intermediate and advanced cervical cancer.Methods Eighty patients with intermediate and advanced cervical cancer were randomly divided into treatment group and control group by random digits table with 40 patients each.The patients in treatment group were received uterine artery chemoembolization and radiotherapy.The patients in control group were received radiotherapy and intravenous chemotherapy.The short-term efficacy,survival and untoward reaction were observed in 2 groups.Results The complete remission rate and objective response rate in treatment group were significantly higher than those in control group [72.5％(29/40) vs.50.0％(20/40),95.0％(38/40) vs.80.0％(32/40),P ＜ 0.05].There was no significant difference in survival rate of 1,2 and 3-year between the 2 groups (P ＞ 0.05).The incidence rates of leukopenia,anemia,thrombocytopenia,nausea and vomiting in treatment group were significantly lower than those in control group [32.5％ (13/40) vs.67.5％ (27/40),30.0％ (12/40) vs.75.0％ (30/40),7.5％ (3/40) vs.17.5％ (7/40),37.5％ (15/40) vs.70.0％ (28/40),P ＜0.05].There were no significant difference in the incidence rates of radiation cystitis and radiation proctitis between the 2 groups (P ＞ 0.05).Conclusion Uterine artery chemoembolization combined with radiotherapy for intermediate and advanced cervical cancer can improve short-term efficacy and with less side effects.
