The expression of oncogene c-myc and its role on human laryngeal cancer
10.3969/j.issn.1001-1781.2009.24.007
- VernacularTitle:癌基因c-myc在喉癌组织中的表达及意义
- Author:
Xiaobo LONG
;
Shuang HU
;
Pingping CAO
;
Zheng LLU
;
Hongtao ZHEN
;
Yonghua CUI
- Publication Type:Journal Article
- Keywords:
oncogene;
c-myc;
laryngeal neoplasms
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;(24):1127-1129
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the expression of oncogene c-myc and explore its role on human aryngeal cancer.Method:The mRNA and of oncogene c-myc levels were detected in human laryngeal cancer tissues and iaryngeal normal tissues by the means of real-time PCR and immunohistochemistry,respectively.Result:Compared with normal laryngeal tissues,the mRNA and protein levels of oncogene c-myc were both upregulated in laryngeal cancer tissues of all differentiation degree(P＜0.05).Moreover,the level of e-myc was inverse correlated with the differentiation degree in human laryngeal cancer tissues.Conclusion:The oncogene c-myc is overexpressed in human laryngeal cancer tissues,and c-myc may play an important role in carcinogenesis and progression of human laryngeal cancer tissues.It may provide a new target for gene therapy of human laryngeal cancer.
