Expression of Toll-like receptors signaling pathway in chronic rhinosinusitis with nasal polyps
10.3969/j.issn.1001-1781.2009.23.002
- VernacularTitle:Toll样受体及其传导通路在慢性鼻窦炎鼻息肉中的表达
- Author:
Xin WANG
;
Chunyuan ZHAO
;
Ming LIU
- Publication Type:Journal Article
- Keywords:
Toll-like receptors;
chronic rhinosinusits;
nasal polyps;
microarry
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;(23):1059-1062
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of Toll-like receptors(TLRs)signaling pathway in chronic rhinosinusitis(CRS)with nasal polyps.Method:Gene microarray analysis was used to detect the expression of TLRs signaling pathway in CRS with nasal polyps.Result:Of 19 differentially expressed(two-fold changes),4genes were upregulated and 15 genes were downregulated.Conclusion:The differentially expressed genes in TLRs signaling pathway may exert its effect in the pathogenesis of CRS.In addition,the roles of TLR9 and its agonists need further study.
