Expression of Runx3 protein and its cliniopathologic significance in gastric carcinoma

VernacularTitle:Runx3蛋白在胃癌中的表达及其临床病理学意义
Author: Jianyun LAN ; Xiumei CHENG ; Sujuan YUAN ; Haitao CHENG
Publication Type:Journal Article
Keywords: stomach neoplasms; Runx3 protein; immnohistochemistry; prognosis
From: Chinese Journal of Clinical and Experimental Pathology 2009;(6):594-597
CountryChina
Language:Chinese
Abstract: Purpose To investigate the relationship between the expression of Runx3 protein and pathogenesis, development,clinicopathological features and its prognostic significance in gastric adenocarcinoma.Methods Immunohistochemical SP method was used to detect the expression of Runx3 protein in 63 cases of gastric cancer,19 cases of atypical hyperplasia and 10 cases of normal gastric mucosa obtained from patients whose partial gastrotomy was performed for benign diseases.Results Compared with gastric atypical hyperplasia tissue (68.4%) and normal gastric mucosa (90%), the positive rate of Runx3 protein in gastric cancer (39.7%) was significantly lower (P＜0.05); the expression of Runx3 protein was related to tumor differentiation, invasive depth and lymphnode metastasis, but not to age, sex, tumor size and TNM stages; the survival rate of the patients with Runx3 protein expression was higher than that without Runx3 expression (P＜0.05).Conclusion Runx3 protein may play an important role in the occurrence and development of gastric cancer, and it is an important marker in evaluating the prognosis of the patients.