Expression of iNOS and COX-2 and their significance in colorectal adenocarcinoma
10.3969/j.issn.1001-7399.2009.06.008
- VernacularTitle:大肠腺癌中iNOS和COX-2的表达及意义
- Author:
Meiling BAI
;
Shuqiang WANG
;
Fan ZHANG
;
Liping GE
;
Linxi ZHANG
;
Xin WU
- Publication Type:Journal Article
- Keywords:
colorect neoplasms;
adenocarcinoma;
iNOS;
COX-2
- From:
Chinese Journal of Clinical and Experimental Pathology
2009;(6):598-600
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the expression and interaction of iNOS and COX-2 in colorectal adenocarcinoma, as well as their relationship with the biological behaviors of colorectal adenocarcinoma.Methods Intestinal biopsy specimens of colorectal adenocarcinoma were collected in the 78 cases and 33 normal intestinal mucosal tissues.The expression of iNOS and COX-2 proteins was detected by immunohistochemical staining (SP method).Results The positive rates of iNOS and COX-2 protein was significantly higher in normal intestinal mucosa than that in colorectal adenocarcinoma (P<0.05).The expression of iNOS and COX-2 protien had significant relation with lymph node metastasis (P<0.05).The positive expression of iNOS and COX-2 in intestinal adenocarcinoma was related with TNM stage:the positive expression in patients with Ⅲ+Ⅳ stage was higher than that with Ⅰ+Ⅱstage (P<0.05). The expression of iNOS was closely correlated with COX-2 (P<0.05).Conclusions The overexpression of COX-2 and iNOS participates in the pathogenesis of colorectal carcinoma and is associated with lymph node metastasis and TNM stage of colorectal adenocarcinoma.The expression of iNOS is correlated with COX-2 in the cancer.
