Expression of p53 and E-cadherin in gastric adenocarcinoma and their relationship with prognosis
10.3969/j.issn.1001-7399.2009.06.009
- VernacularTitle:胃腺癌中p53、E-cadherin的表达及其预后因素分析
- Author:
Hongfeng AO
;
Yong LIU
;
Sheng YUAN
;
Jinping AO
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
adenocarcinoma;
p53;
E-cadherin;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2009;(6):601-605
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the protein expression of p53 and E-cadherin in gastric adenocarcinoma and the effects of them and the clinicopathological parameters on prognosis of patients.Methods Expression of p53,E-cadherin in 150 cases of gastric adenocarcinoma was detected by tissue microarray and immunohistochemistry.The effects of them and the clinicopathological parameters on the prognosis of patients were studied by Kaplan-Meier method to calculate and compare the cumulative survival rate and postoperative mean survival time.Multivariate analysis was also performed by COX regression.Results The positive rate of p53 and E-cadherin expression in 150 cases of gastric adenocarcinoma was 31.3% and 91.3%,respectively.74 cases were followed up, and the 1-,3-,and 5-year survival rates were 83.8%,70.3% and 63.5%,respectively.The invasion, lymph node status and pTNM stages were prognostic factors;multivariate analysis revealed that p53,age and lymph node status were independent prognostic invasion, lymph node status and pTNM stages are important prognostic factors in gastric adenocarcinoma. Nevertheless, E-cadherin and histological classification are not prognostic factors.
