Expression of NF-κB gene and its significance in mouse hepatocellular carcinoma cell lines with differently lymphatic metastasis potentials
10.3969/j.issn.1001-7399.2009.06.014
- VernacularTitle:小鼠肝癌淋巴道转移细胞系中NF-κB基因的表达及意义
- Author:
Xuening JI
;
Xuejun FAN
;
Mei LI
;
Shen Lü
;
Ruoyu WANG
- Publication Type:Journal Article
- Keywords:
liver neoplasms;
NF-κB;
neoplams metastasis
- From:
Chinese Journal of Clinical and Experimental Pathology
2009;(6):624-627
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study NF-κB gene expression level in mouse hepatocellular carcinoma cell lines with differently lymphatic metastasis potentials and to discuss its roles in lymphatic metastasis.Methods Using real-time quantitative PCR, NF-κB gene expression level was detected in mouse hepatocellular carcinoma cell lines, including Hca-P with low lymphatic metastasis potential and Hca-F with high lymphatic metastasis potential.Results NF-κB mRNA expression in Hca-P and Hca-F cell lines were (1.41±0.48)×10~(-3),and (2.95±0.22)×10~(-3) (P<0.01),respectively.NF-κB mRNA expression levels were increased with metastasis potential.Conclusion NF-κB gene may play an important role in lymphatic metastasis of hepatocellular carcinoma.
