The effects of flavonoids extracts from semen Astragali complanali on the growth of liver cancer and immune function
10.3781/j.issn.1000-7431.2009.12.002
- VernacularTitle:沙苑子黄酮抗肝癌生长作用及对免疫功能的影响
- Author:
Cuiping WEI
;
Qiyun TANG
;
Zhongqin LIANG
;
Zhenlun GU
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
experimental;
Semen Astragali complanati;
Flavones;
Immunocompetence;
Mice
- From:
Tumor
2009;(12):1112-1115
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of flavonoids extracts from semen Astragali complanati (FAC) on the growth of hepatocellular H22 cells and elucidate its action mechanism. Methods:The mouse model bearing H22 tumor cells was established. The effects of FAC on the growth of xenografted H22 tumor, the immune organ, survival time, phagocytic function of macrophages, and lymphocyte transformation in tumor-bearing mice were observed. Results:The growth of H22 transplanted tumor was significantly inhibited by FAC at high, middle and low doses,compared with normal control group (P<0.05). The tumor-inhibiting ratio in cyclophosphamide (CTX) group was similar with that in FAC high-dose group (P>0.05). FAC markedly elongated the survival time of tumor-bearing mice. The high, middle and low doses of FAC elongated the survival time of tumor-bearing mice by 64.9%, 56.7% and 28.1%, which were significantly different with control group (P<0.01). The high, middle and low doses of FAC greatly increased the thymus index and spleen index of tumor-bearing mice (P<0.05, vs control) and elevated the phagocytic function of macrophages and lymphocyte transformation capability (P<0.01, vs control). The effect of CTX on immune function of tumor-bearing mice was opposite with FAC. The difference between CTX group and control group was significant (P<0.01). Conclusion: FAC inhibits the growth of H22 hepatoma, elongates the survival time, and elevates the non-specific immune function of tumor-bearing mice, indicating that FAC maybe exert its anti-tumor effect via regulating immune function of tumor-bearing mice.
