Expression of RAGE in laryngeal squamous cell carcinoma and clinical significance

VernacularTitle:晚期糖基化终产物受体在喉鳞状细胞癌中的表达及临床意义
Author: Huiping ZHANG ; Rong ZHANG ; Hanjing SHANGGUAN
Publication Type:Journal Article
Keywords: laryngeal neoplasms; the receptor of advanced glycation end products; immunohistochemistry; RT-PCR
From: Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2009;(21):985-988
CountryChina
Language:Chinese
Abstract: Objective:To study the expression and clinical significance of receptor for advanced glycation end products (RAGE) in laryngeal squamous cell carcinoma (LSCC).Method:Immunohistochemical staining was used to detect the expressions of RAGE protein and semiquantitative method of reverse transcriptase polymerase chain reaction (RT-PCR) was used to analyze the expression level of RAGE mRNA in LSCC tissues and laryngeal normal tissues of 37 cases, respectively.Result:The mRNA and protein expression of RAGE was significantly higher in LSCC than that in normal laryngeal tissues(P<0.05), correlated with differentiation(P<0.01), but not with tumor stage and location(P>0.05).Conclusion:The expression levels of RAGE were significantly higher in LSCC than these in laryngeal normal tissues, RAGE is involved in differentiation of LSCC.