Studies on inhibitive effect of low-voltage electrochemotherapy on head and neck cancer-bearing nude mice

VernacularTitle:低电压电化学疗法对头颈部肿瘤裸鼠移植瘤抑制作用的研究
Author: Xuefeng WANG
Publication Type:Journal Article
Keywords: electrochemotherapy; bleomycin; head and neck cancer
From: Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2009;(21):991-994
CountryChina
Language:Chinese
Abstract: Objective:To analyse the therapic effect of low-voltage electrochemotherapy (EP) on the head and neck cancer.Method:YCU-N861 human head and neck cancer cells were subcutaneously inoculated in the neck of nude mice to establish tumor-bearing models. Then the mice were treated with bleomycin(BLM, 20 μg per mouse), accompanied with electric stimulation(50 V or 100 V).Result:BLM treatment applied with EP can significantly inhibite the proliferation of tumor cells than BLM or EP treatment seperately(P<0.01) . The tumor volume, the mitotic index (MI) and the labeling index (LI) of Ki67 in BLM+EP group were all obviously decreased than BLM group, EP group and control group (P<0.01).Conclusion:Low-voltage electrochemotherapy can offer promising mothod in the local treatment of head and neck cancer.