Expression of Survivin and Bcl-2 in sinonasal inverted papilloma
10.3969/j.issn.1001-1781.2009.20.007
- VernacularTitle:鼻腔鼻窦内翻性乳头状瘤中Survivin及Bcl-2的表达
- Author:
Jinhui LIANG
;
Shan GAO
;
Jian ZHANG
;
Hongmin AO
;
Xianlin WEI
;
Hailin LUO
- Publication Type:Journal Article
- Keywords:
nose neoplasms;
inverted papilloma;
Survivin;
Bcl-2
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;(20):933-935
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of Survivin and it's relationship with the expression of Bcl-2 in sinonasal inverted papilloma (SNIP).Method:Immunohistochemical method was used to determine the expression of Survivin and Bcl-2 in 30 cases of SNIP,10 cases of sinonasal squamous cell carcinoma(SCC) and 10 cases of normal inferior concha tissues.Result:Survivin was expressed in 22 of 30(73.3%)cases of SNIP,8 of 10(80.0%)cases of SCC and not expressed in 10(0%)cases of normal inferior concha tissues.Expression of Survivin was significantly higher in SNIP and SCC than in normal tissues.Bcl-2 was expressed in 9 of 10(90.0%)cases of SCC and 2 of 10(20.0%)cases of normal inferior concha tissues.Expression of Bcl-2 was significantly higher in SCC than in normal tissues.Bcl-2 was expressed in 14 of 30(46.7%)cases of SNIP,higher than normal tissues.Expression of Bcl-2 was positively related to expression of Survivin.Conclusion:Survivin may play an important role in the pathway of progression of SNIP and SCC.It may be identified as a new therapeutic target.Bcl-2 may play a synergic role with Survivin in progression of SNIP.
