Effect of intra nasally applied fluticasone propionate and levocabastine on the expression of aquaporin 5 in nasal mucosa of rat with experimental allergic rhinitis
10.3969/j.issn.1001-1781.2009.20.009
- VernacularTitle:丙酸氟替卡松及左卡巴斯汀对实验性变应性鼻炎大鼠水通道蛋白5的影响
- Author:
Ping LV
;
Suling HONG
- Publication Type:Journal Article
- Keywords:
aquaporin;
rhinitis,allergic;
animal model;
fluticasone propionate;
levocabastine
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;(20):939-941
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and distribution of aquaporin 5(AQP5) in allergic rhinitis(AR)treated by fluticasone propionate and levocabastine.Method:Forty Wister rats were divided randomly into AR(n=30) and control groups(n=10). After AR models were established, the AR rats were divided evenly into F group, L group and AR control group.Three groups were treated respectively for 28 days, then the expression of AQP5 in nasal mucous membrane were detected by immumohistochemistry assay.Result:The distribution of AQP5 was consistent in all groups. The expression of AQP5 in F group was significantly different from L group and AR group (P < 0.05), while there was no significant difference between that of AR group and L group(P>0.05). The expression of AQP5 in L group was significantly different from that in control group(P<0.05).Conclusion:High expressions of AQP5 in rat with AR indicated the positive correlation between AQP5 and AR. AQP5 might be one of pathological factors of AR concered with gland's excessive secretion and tissue edema. Glucocorticoid can down-regulate the expression of AQP5,but H1-receptor antagonist can not reduce the expression of AQP5.
