Progress of pathogenesis and potential future implications of refractory epilepsy
10.3969/j.issn.1000-3606.2009.11.001
- VernacularTitle:难治性癫(癎)的发病机制研究进展及前景展望
- Author:
Shaoping HUANG
;
Dan LI
- Publication Type:Journal Article
- Keywords:
epilepsy;
pharmacoresistance;
reconstitution of neural network;
ion channel;
anti-epileptic drugs;
muhidrug transporter
- From:
Journal of Clinical Pediatrics
2009;(11):1001-1004
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy is a common neurological disorder of children. Research in recent years on the mechanism of refractable epilepsy has made some breakthrough. Four concepts have been put forward to explain the development of pharmacoresistance. The transporter hypothesis have become the focus, which contends that the expression or function of multidrug transporters in the brain is augmented, leading to impaired access of antiepileptic drugs to central nervous system targets. An emerging understanding of these underlying molecular and cellular mechanisms is likely to provide important impetus for the development of new pharmacological treatment strategies and clinical test facility.
