Study on relationship between the level of plasma soluble P-selectin and pediatric migraine
10.3969/j.issn.1000-3606.2009.11.013
- VernacularTitle:血浆可溶性P-选择素与儿童偏头痛关系的研究
- Author:
Bo ZHANG
;
Haibo LI
;
Huilan WU
;
Honghua LU
;
Jiangtao LIU
;
Yuanyuan HUANG
- Publication Type:Journal Article
- Keywords:
migraine;
platelet-activating;
soluble P-selectin
- From:
Journal of Clinical Pediatrics
2009;(11):1051-1053
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the level of plasma soluble P-selectin and pediatric migraine. Methods ABC-ELISA method was used to detect the soluble P-selectin levels in migraine patients (migraine group), migraine patients under control (control group) and healthy children (healthy control group). Transcranial Doppler ultrasound (TCD) and the platelet count were performed. Correlation of P-selectin and platelet count was analyzed. Results Plasma soluble P-selectin level in migraine group was significantly higher than that in the control group and the healthy control group (both P < 0.05). Significant difference was not found between control group and healthy control group (P > 0.05). TCD showed cerebral vasospasm more frequent in the migraine group than the control group, with significant difference (P < 0.05). Blood examination revealed that platelet count of migraine group is higher than that of the control group and the healthy control group, with significant differences (P < 0.05). When migraine was under control, the level of plasma soluble P-selectin reduced to normal and the frequncy of cerebral vasospasm and platelet counts were also within normal range. Plasma soluble P-selectin level and platelet count were positively correlated (r = 0.996, P < 0.01). Conclusions Plasma soluble P-selectin increased in migraine children, the incidence of cerebral vasospasm was significantly increased. Plasma soluble P-selectin level and platelet count were positively correlated. Plasma soluble P-selectin can be used as one of the indicators of diagnosis, treatment and efficacy evaluation in pediatric migraine.
