Studies on p53 in induced pluripotent stem cells
10.3969/j.issn.2095-4344.2013.32.021
- VernacularTitle:诱导多能干细胞与p53基因的研究**☆
- Author:
Tongxiang LIN
;
Yi LIN
- Publication Type:Journal Article
- Keywords:
stem cel s;
stem cel academic discussion;
induced pluripotent stem cel s;
reprogramming;
p53 gene;
stem cel bank;
tumor;
immune rejection;
immunogenicity;
embryonic stem cel s;
National Natural Science Foundation of China
- From:
Chinese Journal of Tissue Engineering Research
2013;(32):5883-5888
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Induced pluripotent stem cel s can bypass the ethical issues of embryonic stem cel s, and become the hotspot of stem cel research. OBJECTIVE:To explore the research progress and problems of induced pluripotent stem cel s. METHODS:A retrospective analysis on the findings, research progress and problems of induced pluripotent stem cel s in recent years was performed. The Thomson Reuters Web of Science was searched for the articles related to the induced pluripotent stem cel s and p53 gene. RESULTS AND CONCLUSION:In recent years, domestic and foreign scholars have conducted a lot of researches on induced pluripotent stem cel s. For example, a Japanese group is establishing the stem cel bank to provide a basis for the treatment of retinal diseases. However, the safety issues of induced pluripotent stem cel s need to be solved before routine cel treatment application, in which the functional research of related p53 gene is one of the essential concerns. The other member of p53 gene, p73 gene, also participates in the generation and differentiation of induced pluripotent stem cel s, and the in-depth studies are needed. The finding of p53 gene function wil promote the in-depth development of regenerative medicine and translational medicine.
