Umbilical cord blood mesenchymal stem cell transplantation for the treatment of renal anemia:Hot spots and issues
10.3969/j.issn.2095-4344.2013.32.023
- VernacularTitle:脐血间充质干细胞移植治疗肾性贫血：热点与问题
- Author:
Kai WANG
;
Hongliang JIAO
;
Jianbin LI
;
Xianming WU
- Publication Type:Journal Article
- Keywords:
stem cel s;
stem cel academic discussion;
renal anemia;
renal failure;
umbilical cord blood;
mesenchymal stem cel s;
hematopoietic stem cel s;
transplantation method;
homing;
erythropoietin;
cytokines
- From:
Chinese Journal of Tissue Engineering Research
2013;(32):5895-5900
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Umbilical cord blood as a source of hematopoietic stem cel s has become a hot topic. Adjuvant therapy of umbilical cord blood transfusion has been used in China to correct renal anemia of uremia patients. OBJECTIVE:To evaluate the efficacy and safety of umbilical cord blood mesenchymal stem cel s in the treatment of renal anemia, and to compare with the effects of different sources of mesenchymal stem cel s with different transplantation methods on the treatment of kidney diseases. METHODS:A retrospective analysis was conducted on six renal anemia patients in the Department of Outpatient, Henan Red Cross Blood Center between January 2010 and December 2012. The experiment was approved by Medical Ethics Committee, six patients were informed consent for treatment programs, and parturients and their families have signed the informed consent. The newborns umbilical cord blood of 80-140 mL were col ected with closed sterile plastic blood bags, and then the separated umbilical cord blood mesenchymal stem cel s were transfused into the renal anemia patients through the superficial vein in the back of the hand with the number of≥1×108/copy, two copies per time, and re-transfused after 4 days, a total of three times. The blood hematocrit, hemoglobin, red blood cel s in urine, renal blood flow changes were observed before and after treatment. RESULTS AND CONCLUSION:The hemoglobin, blood hematocrit, red blood cel s in urine and renal blood flow were significantly increased before and after treatment (P<0.05). Transfusion of multiple copies of umbilical cord blood mesenchymal stem cel s through the superficial vein in the back of the hand is convenient and safe, which is considered as a new method for the treatment of renal anemia. But there are certain limitation in the data and the conclusion as the clinical research was designed as self-control, so further confirm is needed.
