The effect of different analgesia methods on postoperative cellular immune function in patients with radical resection of lung cancer
10.3760/cma.j.issn.1673-4904.2013.18.011
- VernacularTitle:术后不同镇痛方式对肺癌根治术患者术后免疫功能的影响
- Author:
Qing WANG
;
Jun WANG
- Publication Type:Journal Article
- Keywords:
T lymphocytes;
Analgesia,patient-controlled;
Parecoxib
- From:
Chinese Journal of Postgraduates of Medicine
2013;(18):32-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of different analgesia methods on postoperative cellular immune function in patients with radical resection of lung cancer.Methods Fifty patients undergoing selective radical resection of lung cancer were randomly divided into two groups.Group A (25 patients) was given morphine patient-controlled epidural analgesia(PCEA) and group B (25 patients) was given preemptive analgesia with parecoxib combined with morphine PCEA.T-lymphocyte subsets (CD4+,CD8+)and natural killer cell (NK cell) were measured by flow cytometry at preanesthesia,2 h intraoperative,24,48 h postoperative.Results The level of CD4+,CD8+ and NK cell in two groups at preanesthesia had no significant difference (P ＞0.05).The level of CD4+ and CD4+/CD8+ in two groups at 2 h intraoperative,24,48 h postoperative were significantly lower compared with preanesthesia (group A:CD4+:0.252 ± 0.035,0.227 ±0.025,0.248 ± 0.028 vs.0.310 ± 0.032,CD4+/CD8+:1.2 ± 0.1,1.0 ± 0.1,1.1 ± 0.2 vs.1.5 ± 0.2;group B:CD4+:0.265 ± 0.033,0.263 ± 0.028,0.264 ± 0.031 vs.0.312 ± 0.035,CD4+/CD8+:1.3 ± 0.2,1.2 ± 0.1,1.2 ± 0.1 vs.1.4 ± 0.1)(P ＜ 0.05).Compared with group A,the range of descend of CD4+ and CD4+/CD8+ in group B was significantly less at 24,48 h postoperative (P ＜ 0.05).The level of NK cell in two groups at 24,48 h postoperative was significantly lower than preanesthesia(O.112 + 0.019,0.113 + 0.016 vs.0.126 + 0.019 and 0.117 +0.016,0.120 +0.018 vs.0.127 + 0.021) (P ＜0.05).The level of NK cell in group B at 24,48 h postoperative was significantly higher than that in group A (P ＜ 0.05).Conclusion Parecoxib sodium preemptive analgesia combined with morphine PCEA may reduce immune depress in tumor palients by lowering the range of descend of CD4+ and NK cell.
