Resistance to chemotherapy and targeting therapy regarding to microenvironment of cancer stem cells
10.3760/cma.j.issn.1673-4203.2013.06.015
- VernacularTitle:肿瘤干细胞微生景的耐药性及相关靶向治疗
- Author:
Jia WANG
;
Jiwei YU
;
Bojian JIANG
- Publication Type:Journal Article
- Keywords:
Cancer;
Neoplastic stem cells;
Microenvironment/niche;
Drug resistance,neoplasm
- From:
International Journal of Surgery
2013;(6):408-412
- CountryChina
- Language:Chinese
-
Abstract:
Cancer stem cells are special stem cells and are found recently in many tumors,and have the capability of self renewal and differentiation and can gradually differentiate into matured tumor cells to form the primary lesion and the various metastasis lesions of tumors.As well known,cancer stem cells shared strong ability of resistant to chemotherapy and/or radiotherapy,which is mainly related to many kinds of molecules and theirs relative regulation in niche regarding to cancer stem cells.Currently,the strategies of some novel therapies are conducted to detect the targeting sites with relevant to the microenvironments of cancer stem cells,such as the angiogenesis and epithelial-mesenchymal transition of cancer stem cells.Furthermore,insights into drug-resistance of cancer stem cells and its niche may offer new therapeutic strategies for the treatment of tumors.
