Mast cells in the mechanism of action of abdominal aortic aneurysm
10.3760/cma.j.issn.1673-4203.2013.06.011
- VernacularTitle:肥大细胞在腹主动脉瘤中的作用机制
- Author:
Runze SONG
;
Yongzhu YANG
- Publication Type:Journal Article
- Keywords:
Aortic aneurysm,abdominal;
Matrix metalloproteinases;
Mast cells;
Chymotrypsin
- From:
International Journal of Surgery
2013;(6):394-398
- CountryChina
- Language:Chinese
-
Abstract:
Mast cells regulate inflammation and immunity.Experimentally induced abdominal aortic aneurysm in mast cells-deficient animals and animals treated with mast cells inhibitors demonstrate that mast cells are involved in the pathogenesis of abdominal aortic aneurysm via several different mechanisms.Mast cells-dependent activation of metalloproteinases and the renin-angiotensin system,contribution to smooth muscle cell apoptosis,and release of proteolytic enzymes are some key examples.Activated mast cells also contribute to neovascularization,inflammation,and atherosclerosis,all hallmarks of abdominal aortic aneurysm.Thus,we may envision that mast cells stabilizing agents,as well as leukotriene receptor antagonists and histamine receptor blockers already in clinical use for treatment of other diseases,could also be tested for their efficacy in treatment of abdominal aortic aneurysm.
