Current progress of MDM2 inhibitor in urological malignancies
10.3760/cma.j.issn.1673-4203.2013.05.010
- VernacularTitle:MDM2抑制剂在泌尿系统肿瘤方面的研究进展
- Author:
Qingjun LIU
;
Xiuhong XU
;
Ye TIAN
- Publication Type:Journal Article
- Keywords:
MDM2;
Genes,P53;
MDM2 inhibitor;
Protein-protein interaction
- From:
International Journal of Surgery
2013;(5):318-322
- CountryChina
- Language:Chinese
-
Abstract:
The discovery of the key negative regulator MDM2 and the detailed mechanism of MDM2-P53 protein-protein interaction provide a great opportunity to activate P53 by inhibiting MDM2-P53 interaction with MDM2 inhibitor.In this article,the author will review the accomplishment in the area of MDM2 inhibitor treatment on tumors of urological system.The detailed mechanism and the signal pathways involved are summarized simultaneously.
