CELL-SELEX and its applications in leukemia
10.3760/cma.j.issn.1009-9158.2013.04.021
- VernacularTitle:CELL-SELEX技术及其在白血病研究中的应用
- Author:
Xin CHEN
;
Xiaopeng LAN
- Publication Type:Journal Article
- Keywords:
Aptamer;
Leukemia
- From:
Chinese Journal of Laboratory Medicine
2013;(4):377-379
- CountryChina
- Language:Chinese
-
Abstract:
Due to the complicated and changeable clinical symptoms,and inexact pathogenesis,leukemia was facing huge challenges in diagnosis and therapy.Aptamer could be selected through CELL-SELEX.The aptamer not only display high affinity and specificity to target cell,but also it could discriminate the specific stage of cell,such as different classification,normal and tumor cells.So CELL-SELEX has great potention in the researches of leukemia.This paper systematically summarized the advantages of CELL-SELEX,the application in specific leukemia diagnosis,targeted therapy and the discovery of cancer biomarkers.(Chin J Lab Med,2013,36:377-379)
