Association between sialic acid and high sensitivity C-reactive protein in prehypertension patients
10.3760/cma.j.issn.1009-9158.2013.06.009
- VernacularTitle:血清唾液酸和超敏C反应蛋白与高血压前期的相关性研究
- Author:
Yongtong CAO
;
Jinghua LI
;
Ping WANG
;
Tie ZHANG
- Publication Type:Journal Article
- Keywords:
N-acetylneuraminic acid;
C-reactive protein;
Blood pressure;
Hypertension
- From:
Chinese Journal of Laboratory Medicine
2013;(6):516-518
- CountryChina
- Language:Chinese
-
Abstract:
Objeetive To evaluate the serum concentration of sialic acid (SA) and High sensitivity C-reactive protein (hs-CRP) in prehypertension patients and possible correlation of the two factors and blood pressure in prehypertension patients.Methods 61 prehypertension patients,70 hypertension patients and 50 healthy controls were included.Lipid profile,hs-CRP,SA,and body mass index (BMI) were estimated in all the groups.Associations between SA and hs-CRP and blood pressure were analyzed by multiple linear regressions.Results The levels of SA and hs-CRP were higher in the prehypertension group than those in the normal group and lower than those in the hypertension group(P ＜ 0.05).There was significant difference in systolic blood pressure (SBP),diastolic pressure (DBP),BMI and HDL among the three groups(P ＜ 0.05).There was significant difference between the prehypertension group and the hypertension group in LDL,TC and FBG.Multiple linear regression showed that FBG,BMI,SA and hs-CRP were correlated with SBP independently while LDL,BMI,SA and hs-CRP were correlated with DBP independently (P ＜ 0.05).Conclusions The findings of the present study suggest that,there is an association between blood pressure and the levels of serum SA and hs-CRP which might be used as screening biomarkers in prehypertension.
