Resistance mutation during anti-HBV and anti-HCV treatment:question and strategy
10.3760/cma.j.issn.1009-9158.2013.03.001
- VernacularTitle:HBV和HCV耐药与检测监控中的问题与应对策略
- Author:
Lai WEI
;
Ruifeng YANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Hepatitis C virus;
Drug resistance,virue
- From:
Chinese Journal of Laboratory Medicine
2013;(3):193-200
- CountryChina
- Language:Chinese
-
Abstract:
Both long term follow up and real world research on chronic hepatitis B have accumulated data on nucleos (t) ide analogues in anti-HBV treatment,which shows that resistance mutation turns out to be the major obstacle in achieving response.Identification of genotypic resistance at early stage is key to improve strategy.Deep-sequencing will be helpful to predict resistance earlier.Direct acting autiviral agents on hepatitic C virus tell us resistance at the very beginning,however,more data is still needed to elucidate how to use resistance monitoring of anti-HCV treatment.
