Effect of a Dual Drug-Coated Stent With Abciximab and Alpha-Lipoic Acid in a Porcine Coronary Restenosis Model.
10.4070/kcj.2011.41.5.241
- Author:
Kyung Seob LIM
1
;
Young Joon HONG
;
Daisuke HACHINOHE
;
Khurshid AHMED
;
Myung Ho JEONG
;
Jung Ha KIM
;
Doo Sun SIM
;
Min Goo LEE
;
Keun Ho PARK
;
Ju Han KIM
;
Youngkeun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Sun Jung SONG
;
Kyoung Woon JUNG
;
Dong Lyun CHO
;
Jung Chaee KANG
Author Information
1. The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju, Korea. myungho@chollian.net
- Publication Type:Original Article
- Keywords:
Drug-coated stents;
Coronary restenosis;
Platelet aggregation inhibitors;
Antioxidants
- MeSH:
Antibodies, Monoclonal;
Antioxidants;
Coronary Restenosis;
Coronary Vessels;
Drug-Eluting Stents;
Fibrin;
Hyperplasia;
Immunoglobulin Fab Fragments;
Neointima;
Platelet Aggregation Inhibitors;
Random Allocation;
Stents;
Swine;
Thioctic Acid
- From:Korean Circulation Journal
2011;41(5):241-247
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of a stent coated with abciximab and alpha-lipoic acid (ALA) in a porcine coronary overstretch restenosis model. MATERIALS AND METHODS: A total of 10 pigs were randomized into two groups (10 pigs, 10 coronaries in each group) in which the coronary arteries were stented with a dual-coated stent and a bare metal stent (control) by randomization. Stents were deployed with oversizing (stent/artery ratio 1.3 : 1) in the porcine coronary arteries, and histopathology was assessed 28 days after stenting. RESULTS: There was no significant difference in the injury score between the two groups. In the neointima, the lymphohistiocyte count was significantly lower in dual-coat stent group compared with the control stent group (120+/-85 cells vs. 159+/-80 cells, p=0.048). There was no significant difference in the fibrin score between the two groups (0.16+/-0.34 in the dual-coated stent group vs. 0.25+/-0.48 in the control stent group, p=0.446). The neointima area was not significantly different between both groups (1.55+/-0.8 mm2 in dual-coated stent group vs. 1.40+/-0.86 mm2 in the control stent group, p=0.447). CONCLUSION: Although the dual-coated stent with abciximab and ALA showed no significant difference in inhibition of neointimal hyperplasia when compared with the bare metal stent, it was associated with a reduced inflammatory reaction when compared with the control stent in a porcine coronary restenosis model.
