Association of genetic polymorphisms of transcription factor 7-Like 2 gene and post-transplantation diabetes mellitus in Han Zhejiang population
10.3760/cma.j.issn.0254-1785.2013.06.008
- VernacularTitle:浙东地区汉族人群TCF7L2基因与肾移植后糖尿病的相关性研究
- Author:
Guobing WENG
;
Shuwei ZHANG
;
Maomao LI
;
Xuping YAO
;
Honggang QI
;
Yu REN
;
Guanzhong LOU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Kidney transcription;
Genes;
Polymorphism;
single nucleotide
- From:
Chinese Journal of Organ Transplantation
2013;(6):353-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between rs290487,rs7903146 of transcription factor 7-Like 2 (TCF7L2) gene and post-transplantation diabetes mellitus in Han Zhejiang population.Method We genotyped two single nucleotide polymorphisms (SNPs) across the TCF7L2 gene in 90 unrelated post-transplantation type 2 diabetes mellitus (PTDM) patients,112 unrelated non-PTDM patients,and a set of post-transplantation diabetes mellitus patients (n =68).Genotyping was performed using direct sequencing SNP Genotyping Assays.The association of SNPs with post-transplantation diabetes mellitus was analyzed.Result In this study,there was statistically significant difference in the T-allele of TCF7L2.rs7903146 between PTDM group (5.1％) and non-PTDM group (1.3％) (P＜0.05).For rs7903146,the frequencies of genotype C/C,C/T (70.0％) and T/T (35.8％) was statistically significant in PTDM group (P＜0.05).For rs290487,the frequencies of genotype C/C,C/T and T/T was 14.7％,38.2％ and 47.1％ respectively in PTDM group,P＞ 0.05.The incidence of PTDM was significantly higher in patients with the CT genotype (odds ratio 18.54 [95％ CI 1.21-282.26],P =0.03).Conclusion With the current sample size,we found that the CT genotype of rs7903146 was significantly associated with post-transplantation diabetes mellitus.
