Pure red cell apalsia caused by infection of human parvovirus B19 post-renal transplantation: 8 cases report and review
10.3760/cma.j.issn.0254-1785.2013.04.010
- VernacularTitle:肾移植后微小病毒B19感染导致纯红细胞再生障碍性贫血八例
- Author:
Yanyan CHEN
;
Hongfeng HUANG
;
Wenhan PENG
;
Wenqing XIE
;
Xianping YU
;
Jianghua CHEN
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Red-cell aplasia,pure;
Gamma-Globulins
- From:
Chinese Journal of Organ Transplantation
2013;(4):231-234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features,diagnosis and treatment of pure redcell aplasia cased by human parvovirus B19 infection after renal transplantation.Method The clinical data including clinical symptoms and physical signs,laboratory and pathological examinations and outcomes of treatment in 8 cases at our hospital from Aug.2011 to Mar.2012 were analyzed retrospective,and relative literatures were reviewd.Result Pure red-cell aplasia occurred in all 8 cases 1 to 3 months after kidney transplantation,and one case had recurremt pure red-cell aplasia.The manifestations including recurrent reduction of hemoglobin,and pure red-cell aplasia was definitely diagnosed by bone marrow morphology,pathology,and polymerase chain reaction assay PVB19 DNA.Treatment of intravenous immunoglobulin and conversion of tacrolimus into ciclosporin was effective.Conclusion PVB19 is a rare but clinically significant infection that manifests as pure red cell aplasia during the early post-transplantation.Treatment of intravenous immunoglobulin and conversion of tacrolimus into ciclosporin in most cases was effective.
