Multiple primary carcinoma in Chinese hereditary nonpolyposis colorectal cancer patients in Northeast China
10.3760/cma.j.issn.1007-631X.2013.04.002
- VernacularTitle:中国东北地区遗传性非息肉病性结直肠癌家系多原发癌的特点分析
- Author:
Yuanxin TANG
;
Xiaoxia LI
;
Gongping SUN
;
Xin LI
;
Meng ZHAO
;
Yifei YAN
;
Jin MENG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms,hereditary nonpolyposis;
Neoplasms,multiple primary;
Family
- From:
Chinese Journal of General Surgery
2013;(4):253-255
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the familial incidence of multiple primary carcinoma in Chinese hereditary nonpolyposis colorectal cancer patients (HNPCC) in Northeast China.Methods By family line investigation,multiple primary carcinoma (MPC) spectrum' s characteristics of 509 patients in 85 families registered in strict conformity with the HNPCC Amsterdam criteria Ⅱ were analyzed retrospectively.Results Of the 85 HNPCC families,multiple primary carcinoma developed in 55 patients in 25 families,among them 45 patients had metachronous carcinoma in 17 families,16 patients had synchronous carcinoma occurred in 12 families,6 patients with both synchronous carcinoma and metachronous carcinoma in 4 families.Conclusions Multiple primary carcinoma developed in significantly high incidence in Northeast China in Chinese hereditary nonpolyposis colorectal cancer patients,the most common MPC are colorectal cancer and endometrial cancer.
