Huaier granules combined with intraarterial chemoembolization for the treatment of hepatocellular carcinoma
10.3760/cma.j.issn.1007-631X.2013.06.011
- VernacularTitle:明胶海绵微粒与洛铂经肝动脉化疗栓塞联合槐耳颗粒治疗原发性肝癌
- Author:
Guangsheng ZHAO
;
Ying LIU
;
Yuewei ZHANG
;
Chuang LI
;
Shunxiong TANG
;
Jun ZHOU
;
Song LIU
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Drug therapy,combination;
Gelatin sponge,absorbable;
Huaier granules;
Transcatheter intraarterial chemoembolization
- From:
Chinese Journal of General Surgery
2013;(6):440-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of combined transcatheter intraarterial chemoembolization with 350-560 μm gelatin sponge particles and lobaplatin (GSPs-TACE) and oral Chinese herb medication Huaier granules in patients with hepatocellular carcinoma (HCC).Methods This is a case-control,single-institution clinical trial.31 HCC patients receiving GSPs-TACE (group A) were matched with 31 patients receiving GSPs-TACE and Huaier granules (group B).Tumor response was evaluated by CECT using response evaluation criteria in solid tumors at 1 month after initial GSPs-TACE.The overall survival was calculated from the data of initial GSPs-TACE using the Kaplan-Meier method.Results The overall mean follow-up period was 28.7 (range 12-42) months.The overall 6-and 12-month survival rates in group A and group B were 90.3％ and 80.6％ vs 100％ and 93.5％,respectively.There was statistically significant difference in 12-month survival rates (x2 =5.213,P ＜0.05).Median survival time respectively was 17.1 and 20.6 months(x2 =0.745,P ＞0.05).The average TACE times were (4.1 ±7.3) and (2.9 ±8.7) respectively in group A and group B (P =0.01).Tumor objective response rate was statistically different in 6-and 12-month in two arms(x2 =5.945,6.384,P ＜0.05).There was no statistically significant difference in complications (respectively x2 =0.435,0.485,2.037,0.137,0.325,all P ＞ 0.05).Conclusions Huaier granules combined with transcatheter intraarterial chemoembolization with 350-560 μm gelatin sponge particles and carboplatin for HCC is safe and effectively prolongs patients' survival.
