New concept in the pathogenesis of diabetes: glucagonocentric model
10.3760/cma.j.issn.1000-6699.2013.06.002
- VernacularTitle:糖尿病发病机制和治疗的新观念:胰升糖素中心论
- Author:
Jianmin LIU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Pathogenesis;
Management;
Glucagon
- From:
Chinese Journal of Endocrinology and Metabolism
2013;(6):446-447
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] The concept for the pathogenesis of diabetes is now changing from previousinsulinocentric model andinsulin/glucagon bihormonal model to a recentglucagonocentric model.Glucagon excess rather than insulin deficiency may play a more important role in mediating the glucose derangement during insulin insufficiency.Antagonizing glucagon signaling pathway may become a potential therapeutic modality in diabetes.
