Six cases of hypophosphataemic osteomalacia induced by adefovir dipivoxil

VernacularTitle:阿德福韦酯致低磷性骨软化症六例分析
Author: Nan ZHANG ; Mingwei SHAO ; Ai HUANG ; Xialian LI ; Guijun QIN ; Lijuan WANG
Publication Type:Journal Article
Keywords: Adefovir dipivoxil; Renal damage; Fanconi syndrome; Hypophosphataemic osteomalacia
From: Chinese Journal of Endocrinology and Metabolism 2013;(5):414-416
CountryChina
Language:Chinese
Abstract: [Summary] An analysis of clinical data was performed in 6 patients diagnosed as adefovir dipivoxil (ADV)-induced nephropathy in recent 14 months.The results showed that all of six patients suffered from pain over multiple joints after taking ADV 10-20 mg/d for 2-3 years,along with hypophosphatemia,hypouricemia,and raised osteogenesis index.One case had increased serum creatinine,5 cases had hypokalemia,renal glycosuria,and4 cases had albuminuria.Imageological examination showed osteoporosis,osteomalacia,and pseudo fracture.After discontinuance of ADV treatment,joint pain was obviously relieved within 3-6 weeks,blood uric acid level returned to normal within 1-2.5 months,and renal glycosuria and albuminuria disappeared by 1-2 months.The results suggest that after taking ADV for more than two years,attention should be paid to the nephropathy induced by ADV and regular monitoring of renal function,blood electrolyte,and urine should be mandatory.Hypouricemia is a reliable index of diagnosis and treatment in this event.