Clinical application of lithium carbonate on 47 patients with hyperthyroidism

VernacularTitle:碳酸锂治疗甲状腺功能亢进症47例临床观察
Author: Rendong ZHENG ; Kemian LIU ; Xiaoqiu CHU ; Wen CAO ; Lin CAO ; Chao LIU
Publication Type:Journal Article
Keywords: Lithium carbonate; Hyperthyroidism; Liver damage; Leukopenia
From: Chinese Journal of Endocrinology and Metabolism 2013;(5):386-389
CountryChina
Language:Chinese
Abstract: Objective To observe the clinical effect of lithium carbonate on hyperthyroidism.Methods Forty-seven cases of hyperthyroidism with abnormal hepatic function and/or leucopenia were recruited from January 2010 to January 2012.Thyroid function,adverse reactions,and clinical outcome of patients treated with lithium carbonate were observed and recorded before and after treatment.Results Thyroid function,liver function,and leucopenia in all patients were improved markedly after treatment.Among the treated patients,9 cases resulted in complete remission and had the drug discontinued,11 cases received radioactive iodine therapy afterwards,6 cases underwent surgical treatment,16 cases continued to use the same drug,and 5 cases were lost during follow-up.No obvious adverse reaction appeared during the treatment.Conclusions Lithium carbonate can be effectively used in patients with hyperthyroidism complicated by leukopenia or liver damage.It is also indicated during preparation for radioactive iodine or surgical treatment in patients with thyrotoxicosis.