Molecular regulation mechanism of pancreatic islet β-cell remodeling in neonatal stage
10.3760/cma.j.issn.1000-6699.2013.04.022
- VernacularTitle:新生期胰岛β细胞重塑阶段的分子调控机制
- Author:
Jiayu ZHU
;
Xiaohong WU
- Publication Type:Journal Article
- Keywords:
Neonatal period;
Islet β-cell;
Remodeling;
Regulatory mechanism
- From:
Chinese Journal of Endocrinology and Metabolism
2013;(4):351-353
- CountryChina
- Language:Chinese
-
Abstract:
The neonatal period is important for the dramatic increment as well as function improvement of islet β-cell.β-cell mass augmentation is primarily regulated by neogenesis,replication,and apoptosis.The mechanisms involve cell cycle related proteins and mitosis-promoting signaling pathways.This remodeling period has far-reaching effects on the body in adapting to the metabolic needs and regulating glucose homeostasis later in life.
