Relationship between tumor necrosis factor-α and interleukin-6 with hyperuricemia in ethnic Uygur, Kazak,and Han
10.3760/cma.j.issn.1000-6699.2013.04.017
- VernacularTitle:不同民族高尿酸血症与肿瘤坏死因子-α和白细胞介素6的关系
- Author:
Hua YAO
;
Lei MIAO
;
Yuping SUN
;
Hui SHI
;
Sukeerbai MUSILIN
;
Shihua QU
;
Yimin SUN
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-α;
Interleukin-6;
Hyperuricemia;
Uygur;
Kazak;
Han
- From:
Chinese Journal of Endocrinology and Metabolism
2013;(4):331-333
- CountryChina
- Language:Chinese
-
Abstract:
To analyse the relationship between tumor necrosis factor (TNF)-α and interleukin-6 with hyperuricemia in ethnic Uygur,Kazak,and Han in Xinjiang province.1 200 cases of Uygur,Han,and Kazak populations were randomly enrolled.Serum uric acid,triglyceride,total cholesterol,high density lipoprotein-cholesterol,low density lipoprotein-cholesterol,fasting plasma glucose,body weigh and height,waist circumference,and hip circumference were measured.Waist-to-hip ratio and body mass index were calculated,and TNF-α,interleukin-6 were determined.The differences between uric acid and inflammatory factors were statistically significant; The differences in TNF-α was statistically significant between high uric acid group and control group in Uygur and Han,and the differences in interleukin-6 was statistically significant between high uric acid group and control group in Uygur,Kazak,and Han(P＜0.01).TNF-α and interleukin-6 were positively correlated with serum uric acid in Uygur,but in Kazak only interleukin-6 was negatively correlated with serum uric acid,in Han only interleukin-6 was positively correlated with serum uric acid(P ＜ 0.01).Hyperuricemia was associated with inflammatory factors,TNF-α,interleukin-6,but there were ethnic differences among Uygur,Kazak,and Han,thus it may provide people of new ideas for prevention and treatment of hyperuricemia and other related metabolic disorders.
