The association between 8-hydroxy-deoxyguanosine and Graves' ophthalmopathy

VernacularTitle:血清8-羟基脱氧鸟嘌呤水平与Graves眼病关系的临床研究
Author: Chunjian QIU ; Xiaozhen YE ; Yangtian WANG ; Minjuan ZHANG ; Jian WANG
Publication Type:Journal Article
Keywords: Oxidative stress; Serum levels of 8-hydroxy-deoxyguanosine; Graves' ophthalmopathy
From: Chinese Journal of Endocrinology and Metabolism 2013;(4):322-323
CountryChina
Language:Chinese
Abstract: To investigate the role played by 8-hydroxy-deoxyguanosine (8-OHdG) in patients with Graves'ophthalmopathy(GO),and the association between 8-OHdG and the disease activity of GO.Serum levels of 8-OHdG were tested in 48 cases with GO and 30 cases with Graves' disease(GD) without ophthalmopathy.30 healthy subjects participated in this study as controls.8-OHdG was detected by enzyme-linked immunosorbent assay (ELISA).Compared with the controls,the mean level of 8-OHdG in GO patients and GD patients was increased significantly [(2.98±1.33),(2.07±1.30) vs(0.72±0.93)ng/ml,P＜0.05].Mean 8-OHdG level in GO patients was markedly higher when compared to GD patients(P＜0.05).Pearson regression analysis showed that elevated levels of 8-OHdG were significantly correlated with the Clinical Activity Score of GO (r =0.54,P＜0.01).The serum level of 8-OHdG in GO patients was raised obviously,it implies that oxidative stress plays an important role in the pathogenesis of GO,and the serum level of 8-OHdG might act as an activity index of GO.