The comparison of the therapeutic impacts on metabolism in hepatitis C virus and human immunodeficiency virus co-infected patients
10.3760/cma.j.issn.1000-6699.2013.04.011
- VernacularTitle:不同方案治疗丙型肝炎合并艾滋病时的代谢指标对照观察
- Author:
Hongqing SUN
;
Qin HUANG
;
Fang SHEN
;
Min WU
;
Xiaoming ZHOU
;
Weiping CAI
;
Yunwen HU
- Publication Type:Journal Article
- Keywords:
Comparision;
Protease inhibitors;
Non-nucleoside reverse transcriptase inhibitors;
Hepatitis C virus/human immunodeficiency virus co-infection
- From:
Chinese Journal of Endocrinology and Metabolism
2013;(4):311-313
- CountryChina
- Language:Chinese
-
Abstract:
To explore and compare the response of the protease inhibitors or non-nucleoside reverse transcriptase inhibitors-based therapeutic impact on metabolic indices in hepatitis C virus (HCV)/human immunodeficiency virus(HIV) co-infected patients.A randomized,open,and control approach was performed to enroll 273 cases of HCV/HIV co-infected patients on their initial visits and to choose protease inhibitors(PIs group) or non-nucleoside reverse transcriptase inhibitors (NNRTIs group) based therapy treatments for one year.Laboratory results of metabolic indices before and after the treatment were collected.After treatment,the levels of triglyceride in NNRTIs and Pls groups were (1.93 ± 0.99) mmol/L and (1.62 ± 0.93) mmol/L respectively,high density lipoprotein-cholesterol were(1.28 ± 0.55) mmol/L and (1.08 ± 0.53) mmol/L,low density lipoprotein-cholesterol were (2.60 ± 1.44) mmol/L and (2.22 ± 1.16) mmol/L,fasting plasma glucose were (5.92 ± 1.21) mmol/L and (4.79 ± 0.47) mmol/L,serum creatinine were (70.5 ± 14.6) μmol/L and (56.6 ± 8.3) μmol/L,and serum amylase were(66.9 ± 27.5) U/L and(62.7 ± 33.8) U/L respectively.The difference between the two groups was statistically significant(all P＜0.01).There is a therapeutic impact on metabolic indices in patients wtih HCV / HIV co-infection after non-nucleoside reverse transcriptase inhibitors-based regimen.
