Expression of calcium-sensing receptor in papillary thyroid carcinoma

VernacularTitle:钙敏感受体在甲状腺乳头状癌中的表达
Author: Zhenhui YOU ; Gang CHEN ; Baogen ZHANG
Publication Type:Journal Article
Keywords: Calcium-sensing receptor; Papillary thyroid carcinoma; Calcification; Immunohistochemical
From: Chinese Journal of Endocrinology and Metabolism 2013;(4):293-296
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between calcium-sensing receptor's expression and papillary thyroid carcinoma.Methods Seventy cases of postoperative papillary thyroid carcinoma were selected.Immunohistochemical technique was used to detect expression of calcium-sensing receptor in papillary thyroid carcinoma,thyroid benign lesions,and normal thyroid tissue,respectively.SPSS 17.0 statistical analysis was used with non parametric test,P＜0.05 indicated significant difference.Results The expression of calcium-sensing receptor in papillary thyroid carcinoma,benign thyroid,and normal thyroid were significantly different (90％,40％,0％,respectively; P ＜ 0.05).The expression of the calcium-sensing receptor in the group of papillary thyroid carcinoma with calcification was significantly higher than that in thyroid cancer without calcification (P ＜ 0.05).Conclusions This study suggests that the calcium-sensing receptor may be associated with papillary thyroid carcinoma and may play a key role in the calcification of the carcinoma.