The relationship between thyroid autoantibodies and thyroid function in different populations
10.3760/cma.j.issn.1000-6699.2013.04.015
- VernacularTitle:健康人群甲状腺自身抗体与甲状腺功能的关系
- Author:
Zuoliang DONG
;
Laixiang LIN
;
Yina SUN
;
Kaibin SHI
;
Yuqin YAN
- Publication Type:Journal Article
- Keywords:
School children;
Adult;
Pregnant women;
Lactating women;
Thyroid autoantibodies;
Thyroid function
- From:
Chinese Journal of Endocrinology and Metabolism
2013;(4):324-327
- CountryChina
- Language:Chinese
-
Abstract:
To explore the relationship between thyroid autoantibodies and thyroid function in school children aged 8-10 years,adults,pregnant women,and lactating women in China,in order to provide reference for the prevention and monitoring of thyroid disease.Healthy 8-10 years old school children (693 cases),adults (698 cases),pregnant women(325 cases),and lactating women(332 cases) from six iodine sufficient areas were enrolled.Serum TSH,FT4,and FT3 were determined by chemiluminescent immunoassay,while antithyroid antibody by radioimmunoassay.The positive rate of thyroid autoantibodies in females was significantly higher than that in the male (5.6％ vs 2.0％ in school children,and 22.8％ vs 3.2％ in adults) ; while positive rate of autoantibodies in pregnant and lactating women (8.9％,8.7％) were significantly lower than that in the other healthy adult women (22.8％).The incidence of abnormal thyroid function in antibody-positive people was higher than that in negative ones in all groups,and abnormal thyroid function showed mainly as subclinical hypothyroidism.In addition,lactating women with negative autoantibodies presented a higher incidence of abnormal thyroid function,mainly as low FT4.The abnormal thyroid function is related with the positive thyroid autoantibodies,indicating that it is essential to follow-up these people with positive antibodies in order to facilitate prevention,early diagnosis,and treatment of thyroid disease.Reference data for thyroid hormones in lactating women should be establisbed as soon as possible.
