The Effect of Colchicine on Fibroblast Proliferation after Glaucoma Filtering Surgery.
- Author:
Young Suk YU
1
Author Information
1. Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Administration, Oral;
Administration, Topical;
Cicatrix;
Colchicine*;
Collagen;
Cytoplasm;
Drug-Related Side Effects and Adverse Reactions;
Fibroblasts*;
Fibrosis;
Filtering Surgery*;
Glaucoma*;
Intraocular Pressure;
Lip;
Rabbits;
Wounds and Injuries
- From:Journal of the Korean Ophthalmological Society
1988;29(6):1023-1036
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Failure of a glaucoma filtering surgery mainly results from scarring at the filtering wound. Postoperative proliferation of fibroblasts plays an important role in scar tissue formation. Colchicine is a cytoplasmic microtu bule inhibitor capable of inhibiting fibroblast proliferation. The effect of colchicine on fibroblast proliferation at the filtering wound after fiItering surgery was investigated. Posterior lip sclerectomies were performed in each eye of albino rabbits. Under the topical or oral administration of colchicine, intracular pressure, conjunctival fibrosis, histologic finding, and drug toxicity were examined postoperatively. Compared to the untreated groups, reductions of intraocular pressure and conjunctival fibrosis in colchicine-treated groups after filtering surgery were statistically significant(p<0.05), and above changes in the topical administration group were more significant than in the oral administration group(p<0.05). Histologically, reductions of active fibroblasts and collagen fibers at the filltering wound and the subconjunctival area were seen in colchicine-treated eyes. Above findings were more prominent in the topical administration group. There were no ocular and systemic toxicities in both groups. The above results suggest that administration of colchicine, especially topical administration, can increase the success rate of filtering surgery.
