Clinical application of cytokines in acute iatrogenic radiation damage
10.3760/cma.j.issn.0254-5098.2013.03.002
- VernacularTitle:造血生长因子在医源性急性放射病的临床应用
- Author:
Wei WAN
;
Fei DONG
;
Jing WANG
;
Kaichao FENG
;
Liping SU
;
Xu SU
;
Xiaoyan KE
- Publication Type:Journal Article
- Keywords:
Cytokine;
Hematopoietic growth factors;
Iatrogenic acute radiation disease
- From:
Chinese Journal of Radiological Medicine and Protection
2013;(3):228-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of hematopoietic growth factors on the TBI patients in the conditioning regimen for stem cell transplantation,and to evaluate the effect of cytokines on treatment of acute radiation disease.Methods The usage of hematopoietic growth factors,implantations and the side-effects of the patients and donors of TBI in the conditioning regimen for stem cell transplantation were retrospectively analysed from 1990 to 2012,and the effect and side-effects of cytokines on the hematopoietic function recovery and stem cell mobilization were observed.Results All patients recovered from their hematopoietic function except one died due to the side-effecs.The median time of white blood cell recover was 10 d in auto-SCT and 12 d in allo-SCT in the G-CSF group.The median day of platelet recovery was 11.67 ± 1.53 in rhIL-11 arm and 13.70 ±6.27 in no rhIL-11 arm in the auto-SCT group.The incidence rates of dental ulcer and diarrhea in the TBI patients were 48％ and 44％,respectively.The occurrence of side-effect was rare in the period of cytokines treatment,but was over 50％ during stem cell mobilization.Conclusions Cytokines play very important roles in the hematopoietic function recovery and stem cell mobilization in the TBI patients.
